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Diabetes February 2, 2026 7 min read

Starting Insulin: A Framework for New Clinicians

How to choose the first regimen, titrate safely, and counsel patients through the emotional barrier of starting injectable therapy.

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Dr. Marufa Mustari

Endocrinologist

Starting Insulin: A Framework for New Clinicians
Insulin initiation is one of the most emotionally charged conversations in diabetes care. Patients often see it as failure. Frame it as progression, not defeat. Start with basal insulin — typically 10 units at bedtime, or 0.1–0.2 units/kg. Titrate by 2 units every three days until the fasting target is met. Hypoglycaemia is the rate-limiting adverse effect. Teach patients to recognise it, treat it with 15g of glucose, and adjust doses accordingly. Revisit the regimen at every visit. Insulin needs change with weight, activity, and comorbidities. A static prescription is rarely the right one.

How to choose the first regimen, titrate safely, and counsel patients through the emotional barrier of starting injectable therapy.

— Dr. Marufa Mustari

#diabetes#endocrinology#clinical-notes
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Dr. Marufa Mustari

Endocrinologist and academic clinician, writing on diabetes, thyroid, reproductive endocrinology, and medical education for residents and students.

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